Therapeutic Alternatives for The Treatment and Prevention of Dilated Cardiomyopathy (DCM): The Era of Biological Agents-Juniper Publishers
Pharmacology & Clinical Research-Juniper Publishers Abstract Dilated Cardiomyopathy is a rare condition that can be caused by a variety of common morbidities. It is an immune mediated disease, characterized by chronic stimulation of inflammatory responses. The so far available treatment consists of agents that ameliorate only the functional burden off the circulatory system. Biological therapies have been successfully applied in several diseases derived from hyper activation of the immune system. In this mini review we investigate whether abatacept, a biological agent targeting co-stimulation, could be beneficial in inhibiting pathophysiological progression of DCM. Dilated Cardiomyopathy–Introduction Dilated cardiomyopathy is the most common cardiomyopathy. It reflects a functional state where the anatomic structures of the heart cannot support a proper blood circulation. Dilated cardiomyopathy is not