Juniper Publishers-Cancer Therapy Oncology International Journal

  Cancer Therapy & Oncology- Juniper Publishers                                                    Abstract Gastric Cancer (GC) is the fourth common cancer worldwide. It has a geographical distribution affecting mainly the developing countries much more than the developed ones. It is an aggressive disease with poor outcome. Little breakthroughs were achieved in the treatment of GC in the last few decades. These were confined to chemotherapy and surgical techniques. The development of gastric cancer is a complex, multistep process, which involves multiple genetic and epigenetic alterations. The previous classifications of GC had limited impact on its management and prognosis. A novel molecular classification will enhance our understanding of the cancer of the stomach and it will individualize our therapy in a targeted manner for more robust results an...

Cancer Therapy & Oncology- Juniper Publishers Abstract Everolimus, an mTOR inhibitor, perifosine, an AKT inhibitor, enzastaurin, a phosphatidylinositide3 kinase/AKT inhibitor, panobinostat, a histone deacetylase inhibitor, ofatumumab, a third-generation anti-CD20 monoclonal antibody, and ibrutinib, a Bruton tyrosinekinase inhibitor, and newer drugs from known active subclasses, such as pomalidomide (immunomodulatory) and carfilzomib (proteasome inhibitor) arepromising drugs in various stages of study in WM. They may expand future treatment options. Abbreviations: WM: Waldenström’s Macroglobulinemia, LPC: Lymphoplasmacytic, MYD: Myeloid Differentiation Primary Response Gene, IgM: Immunoglobulin M, CNS: Central Nervous System, DLBCL: Diffuse Large B-Cell Lymphoma, ATM: Ataxia Telangiectasia-Mutated, BTK: Bruton’s Tyrosine Kinase, IRAK1: Interleukin-1 Receptor-Associated Kinases, WHIM: Warts Hypogamma globulinemia Infections Myelokathexis, WT: Wild-Type, ERK: Extrace...

 Cancer Therapy & Oncology - Juniper Publishers Abstract International organization of standardization (ISO) has the responsibility of forming international standards across the globe. The technical community of international organization of standards drafts international standards as per the rules and directive. Most medical device manufacturers use ISO 13485 as the quality management system to demonstrate their ability for consistency in design, development, and safe delivery for their medical devices and related services meeting regulatory compliance and customer needs. ISO13485: 2016 replaces the 2003 version and will be mandatory for device manufacturers to transition over within three years. ISO 14971 is a standard for risk management for medical devices. FDA terms it as acceptable whereas in Europe it is mandatory Keywords: ISO 13485:2016; ISO 14971; Medical device; Quality management system; Risk Abbreviations: ISO: International Organization of Stan...

 Cancer Therapy & Oncology - Juniper Publishers Abstract Owing to the high prevalence of gynecological malignancies worldwide, it is of utmost importance to detect these malignancies early, thus reducing their morbidity and mortality rates. Imaging plays a significant role not only in detection but also, owing to the new functional techniques including perfusion MRI, in staging and directing treatment planes. In this article we review the different perfusion techniques used in endometrial, cervical and ovarian malignancies and the importance and potential benefits for their use. The importance of early and proper diagnosis of gynecologic malignancies lies in the fact that they contribute to a large number of female mortality and morbidity in the United States. Abbreviations: MRI: Magnetic Resonance Imaging; DCE-MRI: Dynamic Contrast Enhanced MRI; MVD: Microvessel Density; VEGF: Vascular Endothelial Growth Factor; IAUGC: Initial Area Under the Gadolinium Concen...

Cancer Therapy & Oncology - Juniper Publishers Abstract The problem of cancer in Africa is so dire that international institutions are predicting “ a new scourge on a huge scale, one which, both directly and through its enomic impact, will increase poverty, misery and the death rate”. A comprehensive policy response is therefore urgently needed and it’s a duty to unravel the assertion that theses pathologies are restricted to high income nations. A global and coherent health program must be built and implemented at the national, regional and continental levels. To address this epidemiologic challenge, one the first steps will be the international cooperation and coordination based on resolute actions and programmes. Keywords: Cancer, Africa, developing countries, Non Communicable Diseases, Global health Introduction Even in developing countries such as African countries non communicable diseases (NCDs) are among le...