Juniper Publishers-Cancer Therapy Oncology International Journal

Cancer Therapy & Oncology - Juniper Publishers Abstract The problem of cancer in Africa is so dire that international institutions are predicting “ a new scourge on a huge scale, one which, both directly and through its enomic impact, will increase poverty, misery and the death rate”. A comprehensive policy response is therefore urgently needed and it’s a duty to unravel the assertion that theses pathologies are restricted to high income nations. A global and coherent health program must be built and implemented at the national, regional and continental levels. To address this epidemiologic challenge, one the first steps will be the international cooperation and coordination based on resolute actions and programmes. Keywords: Cancer, Africa, developing countries, Non Communicable Diseases, Global health Introduction Even in developing countries such as African countries non communicable diseases (NCDs) are among le...

  Cancer Therapy & Oncology International Journal Abstract Neurofibromatosis was first described in 1882 by Friedrich Daniel von Reckling hausen, a German pathologist. Neurofibroma is a benign peripheral nerve sheath tumor that consists of Schwann cells, associated or unassociated with axons, perineural cells, and fibroblasts. Whenever possible, the treatment of choice should be surgical, but the management depends on the location and growth pattern. We present the case of a patient with left axillary neurofibroma without neurofibromatosis (NF) in whom surgery was delayed due to involvement of the brachial plexus, so was sent to radiotherapy, planned and treated with volumetrically modulated arc therapy (VMAT). Keywords: Neurofibroma; VMAT; Radiotherapy; Axillary Tumor; INCART Abbreviations: NF: Neurofibromatosis; VMAT: Volumetrically Modulated Arc Therapy; CRO: Radiation Oncology Center; INCART: Institute Rosa Emilia Sánchez Pérez de Tavares; ...

  Cancer Therapy & Oncology International Journal Abstract Multiple myeloma (MM) is a malignant disorder of antibody-producing clonal plasma cells. It is the second most common hematologic neoplasia worldwide [1]. Despite recent advances in myeloma treatment (high-dose chemotherapy followed by autologous stem cell transplantation, novel immunomodulatory drugs, and proteasome inhibitors); MM remains largely incurable with chemotherapy [2]. This is mostly due to the persistence of minimal residual disease (MRD), which leads to high relapse rates [2]. Furthermore, the prognosis of MM patients who become refractory to recently developed novel agents is very poor [1]. Abbreviations: MM: Multiple Myeloma; MRD: Minimal Residual Disease; PD-L1: Programmed Cell Death Ligand; MDSCs: Myeloid-Derived Suppressor Cells; ACT: Adoptive Cellular Therapy; SLAMF7: Signaling Lymphocyte Activating-Molecule Family Member 7; ADCC: Antibody-Dependent Cellular Cytotoxicity;...

  Cancer Therapy & Oncology International Journal    Abstract Prostate cancer within a younger cohort of men continues to be an increasing problem. With a younger population, greater expectations are present, from erectile function, to continence to oncological outcomes. Significant prostate cancer is increasingly diagnosed in younger men, less than 55 years [1]. In a non-screened population young patients are choosing radical surgery for intermediate and high risk disease [1]. This patient group have high expectations with regards to oncological and functional outcomes. The next question arises, what can we do to improve outcomes? Keywords: robotic radical prostatectomy, outcomes Abbreviations: ERSPC: European Randomized Study of Screening for Prostate Cancer; AUA: American Urological Association Mini Review Early-onset prostate cancer (<55 years), dif...

  Cancer Therapy & Oncology International Journal Abstract Neurofibromatosis type 1 (NF1), formerly known as von Recklinghausen’s disease is a nervous system tumor disorder of variable expressivity. Malignant solitary fibrous tumors (SFT) are rare spindle cell soft tissue tumors. We report a case of a 35-year-old male who presented clinically with NF1 and a mass that mimicked a nerve sheath tumor radiologically, but pathologically was, in fact, a malignant solitary fibrous tumor. Based on a literature review, the association between NF1 and malignant SFT has never been published. Keywords: Neurofibromatosis type 1; Malignant solitary fibrous tumor Abbrevations: SFT: Solitary Fibrous Tumors; NF1: Neurofibromatosis type 1 Mini Review Neurofibromatosis type 1 (NF1) is a multisystem disease characterized by cutaneous findings, as well as benign and malignant tumors o...

  Cancer Therapy & Oncology International Journal Abstract Introduction and Objective: Clinical studies have demonstrated synergistic antitumor effects of chemotherapy (CT) and zoledronic acid (AZ). In the essay Neo - AZURE, to determine whether the addition of AZ to neoadjuvant chemotherapy gives compléte histological responses. We report a prospective evaluation comparing compléte pathological response between different subs - biomolecular groups. Methods: From 2012 to 2014, 432 patients received neoadjuvant chemotherapy + AZ. The main objective is the complete histologic response. Secondary endpoints were clinical response according to RECIST criteria, estimate the overall survival of patients targeted by the study, assess bone density before and at the end of chemotherapy, the side effects associated with the treatment protocol, and Quality life Results: histologic complete response with zoledronic acid was 40.13% .the higher in the subgro...