Juniper Publishers-Cancer Therapy Oncology International Journal

Cancer Therapy & Oncology- Juniper Publishers                                               Abstract In the 2016 version of WHO classification, bone marrow morphology is critical in the distinction between ET and pre-PMF. Reticulin-fiber grading becomes central: grade 1 or less is needed for ET. Furthermore,  CALR  assessment must be performed in all ET patients without  JAK2  mutation. Some prognostic implications have been described for  CALR  mutations, i.e., a lower risk of thrombosis in ET. Abbreviations:  MPN: Myelo Proliferative Neoplasm; WHO: World Health Organization; JAK: Janus kinase; CALR: Calreticulin; bp: base pair; MPL: Myelo Proliferative Leukemia virus oncogene; TPO: Thrombo Protein; RARS-T: Refractory Anemia with Ring Sideroblasts associated with marked Thrombocytosis; PMF: Primary Myelo Fibrosis; IPSET: The International Prognostic Score for Essential Thrombocythemia; WBC: White Blood Cell; LMWH: Low-Molecular Weight Heparin; SVT: Splanchnic Vein Thrombosis Intro

  Cancer Therapy & Oncology- Juniper Publishers                                                      Abstract Introduction Lymphoma has been historically divided into a Hodgkin and Non-Hodgkin variety. There are reported cases of Hemolytic Anemia in Non- Hodgkin Lymphoma but Hodgkin Lymphoma very rarely also present with Hemolytic Anemias. Case presentation A 27-year-old African woman presented with chronic fatigue, dyspnoea, jaundice and Splenomegalie. Her blood work revealed severe anaemia (haemoglobin, 4.9 g/dl) with biochemical evidence of haemolysis. A direct Coomb's test was reported positive. A biopsy of the lymph nodes in the neck confirmed Hodgkin Lymphoma. Initial therapy consisted of intravenous methyl prednisolone and switched over to Oral Prednisolone. However, the patient came back with raised sugar levels and there was no clinically response. The patient continued to have lower hemoglobin levels and was transfused blood repeatedly. She was started on chemotherapy

  Cancer Therapy & Oncology- Juniper Publishers                                                      Abstract A Birmingham (UK) group considered in 1980 that the establishment of a Histopathology data pool encourages epidemiologic analysis. Consequently, the senior author (WIBO) had such an advantageous opportunity. Interestingly, the junior author (GEN), working in a near Surgical Outpatient Clinic, was consulted by a gravid 5, para 8, patient, i.e., one twin and a set of triplets. Moreover, she also developed 3 breast carcinomas. Therefore, this paper is documented in order to stimulate worldwide interest in this peculiar combination. Is it only happenstance or an explicable natural event?. Keywords:  Breast, triple cancer, pregnancy, triplets, Igbos, epidemiology Introduction The breast has for centuries been the medical man’s talking point. Thus, as the physician/historian, Henry Sigerist, summed it up, "it was chiefly cancer of the breast that attracted the physician’s at

Cancer Therapy & Oncology- Juniper Publishers                                                      Abbreviations cfDNA: Cell-Free DNA; NGS: Next-Generation Sequencing; WGS: Whole Genome Sequencing; WES: Whole Exome Sequencing; GH: Guardant Health; CT: Circulogene Theranostics Editorial Targeted therapy specifically aims at tumor genetic alterations s the hallmark of precision medicine. Companion diagnostic testing utilized to determine the presence or absence of certain oncogenic mutations prior to targeted treatment under the current medical guidelines will enable improved clinical outcome, and thus serves as a vital component for precision medicine. Standard clinical practice to assess genetic mutations in cancer patients has historically been through direct sampling of tumor tissue with biopsy or surgical resection. Unfortunately, tissue biopsy is one-time single-site sampling, painful, costly, and can miss the dynamics of tumor clonally evolution during disease progression. The

  Cancer Therapy & Oncology- Juniper Publishers                                                    Abstract Popularized as the “Sister Joseph’s nodule” is the metastatic lesion of the umbilicus. Hitherto, cases had been reported worldwide. Therefore, this article aims to document the patterns of it obtained among an ethnic group in a developing community. Incidentally, a few indigenous doctors suspected the lesions to be of the Sister Joseph nodule type. The epidemiological data included equality of sex and the preponderance of adenocarcinomas. Keywords:  Carcinoma; Umbilicus; Metastasis; Age; Type; Sister Joseph Nodule Introduction Metastatic carcinoma of the umbilicus gained prominence when, “during the early days of the Mayo Clinic, Sister Mary Joseph, the superintendent of St. Mary’s Hospital and Dr. William Mayo’s frequent first assistant, imparted this clinical observation to Dr. Mayo after noting a firm nodule of the umbilicus in many patients with intra-abdominal cancer” [1