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Drivers of Precision Medicine: Liquid Biopsy and Next-Generation Sequencing

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Cancer Therapy & Oncology- Juniper Publishers                                                      Abbreviations cfDNA: Cell-Free DNA; NGS: Next-Generation Sequencing; WGS: Whole Genome Sequencing; WES: Whole Exome Sequencing; GH: Guardant Health; CT: Circulogene Theranostics Editorial Targeted therapy specifically aims at tumor genetic alterations s the hallmark of precision medicine. Companion diagnostic testing utilized to determine the presence or absence of certain oncogenic mutations prior to targeted treatment under the current medical guidelines will enable improved clinical outcome, and thus serves as a vital component for precision medicine. Standard clinical practice to assess genetic mutations in cancer patients has historically been through direct sampling of tumor tissue with biopsy or surgical resection. Unfortunately, tissue biopsy is...
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A Young Woman with Coomb's Positive Severe Haemolytic Anaemia and Hodgkin Lymphoma that Responded Completely to Rituximab: A Case Report

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  Cancer Therapy & Oncology- Juniper Publishers                                                      Abstract Introduction Lymphoma has been historically divided into a Hodgkin and Non-Hodgkin variety. There are reported cases of Hemolytic Anemia in Non- Hodgkin Lymphoma but Hodgkin Lymphoma very rarely also present with Hemolytic Anemias. Case presentation A 27-year-old African woman presented with chronic fatigue, dyspnoea, jaundice and Splenomegalie. Her blood work revealed severe anaemia (haemoglobin, 4.9 g/dl) with biochemical evidence of haemolysis. A direct Coomb's test was reported positive. A biopsy of the lymph nodes in the neck confirmed Hodgkin Lymphoma. Initial therapy consisted of intravenous methyl prednisolone and switched over to Oral Prednisolone. However, the patient came back with raised sugar levels and there was no clinical...
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Juniper Publishers - Role of Distal loopogram Before Defunctioning Stoma Reversal- Results From An Indian Tertiary-Care Center

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  Cancer Therapy & Oncology International Journal Abstract Aim: To determine the utility of routine distal loopogram before stoma reversal and its impact on the management of patients with a low rectal anastomosis. Methods: This is a retrospective review of a prospectively maintained database of the patients underwent stoma reversal between June 1, 2011, and July 31, 2015. Primary variable assessed was accuracy of findings on preoperative distal loopogram in predicting postoperative complications after stoma reversal. Secondary variable was accuracy of findings on colonoscopy in predicting postoperative complications after stoma reversal. Results: One hundred fifty-seven patients who underwent stoma reversal were included in the study. Distal loopogram was found to be abnormal in 23 patients (15%). Overall, 17 patients developed postoperative complication in the form of anastomotic leakage or subacute intestinal obstruction. Colo...
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