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Recent Advance in Diagnosis, Pathogenesis and Risk Stratification of Essential Thrombocythemia

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Cancer Therapy & Oncology- Juniper Publishers                                               Abstract In the 2016 version of WHO classification, bone marrow morphology is critical in the distinction between ET and pre-PMF. Reticulin-fiber grading becomes central: grade 1 or less is needed for ET. Furthermore,  CALR  assessment must be performed in all ET patients without  JAK2  mutation. Some prognostic implications have been described for  CALR  mutations, i.e., a lower risk of thrombosis in ET. Abbreviations:  MPN: Myelo Proliferative Neoplasm; WHO: World Health Organization; JAK: Janus kinase; CALR: Calreticulin; bp: base pair; MPL: Myelo Proliferative Leukemia virus oncogene; TPO: Thrombo Protein; RARS-T: Refractory Anemia with Ring Sideroblasts associated with marked Thrombocytosis; PMF: Primary Myelo Fibrosis; IPSET: The Internati...
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Is The Begetting of Triplets Associated With The Developing of 3 Breast Primaries?

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  Cancer Therapy & Oncology- Juniper Publishers                                                      Abstract A Birmingham (UK) group considered in 1980 that the establishment of a Histopathology data pool encourages epidemiologic analysis. Consequently, the senior author (WIBO) had such an advantageous opportunity. Interestingly, the junior author (GEN), working in a near Surgical Outpatient Clinic, was consulted by a gravid 5, para 8, patient, i.e., one twin and a set of triplets. Moreover, she also developed 3 breast carcinomas. Therefore, this paper is documented in order to stimulate worldwide interest in this peculiar combination. Is it only happenstance or an explicable natural event?. Keywords:  Breast, triple cancer, pregnancy, triplets, Igbos, epidemiology Introduction The breast has for centuries been the medical man’s talking po...
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