Blinded Independent Central Imaging in Clinical Trials: Does it ensure Against Bias?



Authored by Sunil Aggarwal

Blinded independent central imaging reads (BICR) are compared against the local evaluation of site. In clinical trials, it has been noted that BICR have lesser bias in comparison to local evaluation. The discordance rates in central reads may still exist but its advantages over weighs the existing dis-advantages. Overall survival measurement still remains the gold standard for any compound efficacy although progression free survival measurement needs to be well documented, if a compound is so tested. There is always a potential for informative censoring with central reads.

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