Multiple Metastatic Small Cell Carcinoma of Unknown Primary Diagnosed on Inguinal Node Biopsy- Juniper Publishers
Cancer Therapy and Oncology — Juniper Publishers Abstract Poorly differentiated neuroendocrine tumors are uncommon neoplasms of the lung and the gastrointestinal tract. However, 3–5% of these tumors are diagnosed as metastatic disease with unknown primary. Here, we describe a case of neuroendocrine small cell carcinoma of unknown primary diagnosed by inguinal node biopsy. A 53-year-old male patient with a history of heavy smoking presented with cough, back pain and altered mental status. Whole body imaging studies (CT — MRI — FDG PET) favored a diagnosis of hematological disease (lymphoma) or diffuse metastatic melanoma. However, inguinal node biopsy revealed morphological and immunohistochemical features of a neuroendocrine carcinoma, probably originating from the lung. The patient received palliative whole brain irradiation and etoposide/platinum-based chemotherapy. Abbreviations: CUP: Cancer of Unknown Primary; IHC: Immunohistochemistry; CT: Computed Tomograp