Juniper Publishers-Cancer Therapy Oncology International Journal

Pharmacology & Clinical Research-Juniper Publishers Abstract Dilated Cardiomyopathy is a rare condition that can be caused by a variety of common morbidities. It is an immune mediated disease, characterized by chronic stimulation of inflammatory responses. The so far available treatment consists of agents that ameliorate only the functional burden off the circulatory system. Biological therapies have been successfully applied in several diseases derived from hyper activation of the immune system. In this mini review we investigate whether abatacept, a biological agent targeting co-stimulation, could be beneficial in inhibiting pathophysiological progression of DCM. Dilated Cardiomyopathy–Introduction Dilated cardiomyopathy is the most common cardiomyopathy. It reflects a functional state where the anatomic structures of the heart cannot support a proper blood circulation. Dilated cardiomyopathy is not ...

Cancer Therapy and Oncology — Juniper Publishers Abstract Poorly differentiated neuroendocrine tumors are uncommon neoplasms of the lung and the gastrointestinal tract. However, 3–5% of these tumors are diagnosed as metastatic disease with unknown primary. Here, we describe a case of neuroendocrine small cell carcinoma of unknown primary diagnosed by inguinal node biopsy. A 53-year-old male patient with a history of heavy smoking presented with cough, back pain and altered mental status. Whole body imaging studies (CT — MRI — FDG PET) favored a diagnosis of hematological disease (lymphoma) or diffuse metastatic melanoma. However, inguinal node biopsy revealed morphological and immunohistochemical features of a neuroendocrine carcinoma, probably originating from the lung. The patient received palliative whole brain irradiation and etoposide/platinum-based chemotherapy. Abbreviations:  CUP: Cancer of Unknown Primary; IHC: Immunohistochemistry; CT: Computed Tomo...

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Juniper Publishers: Heavy Metal Bioaccumulation by Cestode Parasites o... : Journal of Dairy & Veterinary Sciences   The environment of the Bahía Blanca estuary is considered a hot spot in terms of polluti...

Cancer Therapy & Oncology-Juniper Publishers Introduction Differentiated thyroid cancer in young adults has an excellent prognosis with a long-term survival of over 90%. Radioactive iodine (RA1131) plays an important role in ablating thyroid remnants following thyroid surgery and is also used to treat residual, recurrent or metastatic disease. Its effects on the gonads and fertility are therefore of concern [1]. Keywords RAI131; Fertility; Thyroid cancer RA1131 and Male Fertility After RA1131 administration, testicular irradiation derives from free RA1131 that circulates in the blood and accumulates in the bladder, gut and any functioning metastases close to the testis causing testicular exposure to radiation. Later, the irradiation derives from RA1131 iodoproteins released in blood from damaged thyroid remnants or metastatic lesions. Radio-iodinated thyroglobulin and thyroxine disappear from the blood with half-lives of 3.2 and 10.1 days respectively, contributing...