Juniper Publishers-Cancer Therapy Oncology International Journal

  Cancer Therapy & Oncology- Juniper Publishers                                                    Abstract Medical imaging has always been an essential component of patient management. The pixel/voxel- based machine learning (PML) in medical imaging is gaining momentum as a computer aided diagnostic (CAD) tool if it can achieve better results than radiologists, in terms of detection and bringing down costs. CAD detection of breast cancer in mammograms is one area that has proved to be smarter, but again most radiologists are suspicious of eventual outcome. Machine learning using pixel/voxel values in medical images has shown emergence as a better diagnostic tools than the segmentation or feature based input. Pixel/Voxel based calculations avoid error that is inherent to segmentation based information. Once regulatory information is used as a metadat...

  Cancer Therapy & Oncology- Juniper Publishers                                               Abstract Adenoid cystic carcinomas (ACC) represent 10% of all salivary tumors. It primarily affects the salivary glands particularly those located in the buccal cavity. Sinonasal location is rarely described [1]. We report a rare case of sinonasal adenoid cystic carcinoma (SACC), we discuss through a brief review of the literature its clinical, radiological, histopathological and therapeutic modalities and the prognostic factors of this tumor. Keywords:  Adenoid Cystic Carcinoma; Paranasal Sinus; Facial Pain Introduction ACC is a rare malignant neoplasm that accounts for 1-2% of all head and neck malignancies and approximately 10% of all salivary gland neoplasms [2]. It occurs predominantly among women, between the fifth and sixth decades of life [3]. Sinonasal Adenoc...

  Cancer Therapy & Oncology- Juniper Publishers                                                    Abstract Gastric Cancer (GC) is the fourth common cancer worldwide. It has a geographical distribution affecting mainly the developing countries much more than the developed ones. It is an aggressive disease with poor outcome. Little breakthroughs were achieved in the treatment of GC in the last few decades. These were confined to chemotherapy and surgical techniques. The development of gastric cancer is a complex, multistep process, which involves multiple genetic and epigenetic alterations. The previous classifications of GC had limited impact on its management and prognosis. A novel molecular classification will enhance our understanding of the cancer of the stomach and it will individualize our therapy in a targeted manner for more robust results an...

Cancer Therapy & Oncology- Juniper Publishers Abstract Everolimus, an mTOR inhibitor, perifosine, an AKT inhibitor, enzastaurin, a phosphatidylinositide3 kinase/AKT inhibitor, panobinostat, a histone deacetylase inhibitor, ofatumumab, a third-generation anti-CD20 monoclonal antibody, and ibrutinib, a Bruton tyrosinekinase inhibitor, and newer drugs from known active subclasses, such as pomalidomide (immunomodulatory) and carfilzomib (proteasome inhibitor) arepromising drugs in various stages of study in WM. They may expand future treatment options. Abbreviations: WM: Waldenström’s Macroglobulinemia, LPC: Lymphoplasmacytic, MYD: Myeloid Differentiation Primary Response Gene, IgM: Immunoglobulin M, CNS: Central Nervous System, DLBCL: Diffuse Large B-Cell Lymphoma, ATM: Ataxia Telangiectasia-Mutated, BTK: Bruton’s Tyrosine Kinase, IRAK1: Interleukin-1 Receptor-Associated Kinases, WHIM: Warts Hypogamma globulinemia Infections Myelokathexis, WT: Wild-Type, ERK: Extrace...

 Cancer Therapy & Oncology - Juniper Publishers Abstract International organization of standardization (ISO) has the responsibility of forming international standards across the globe. The technical community of international organization of standards drafts international standards as per the rules and directive. Most medical device manufacturers use ISO 13485 as the quality management system to demonstrate their ability for consistency in design, development, and safe delivery for their medical devices and related services meeting regulatory compliance and customer needs. ISO13485: 2016 replaces the 2003 version and will be mandatory for device manufacturers to transition over within three years. ISO 14971 is a standard for risk management for medical devices. FDA terms it as acceptable whereas in Europe it is mandatory Keywords: ISO 13485:2016; ISO 14971; Medical device; Quality management system; Risk Abbreviations: ISO: International Organization of Stan...

 Cancer Therapy & Oncology - Juniper Publishers Abstract Owing to the high prevalence of gynecological malignancies worldwide, it is of utmost importance to detect these malignancies early, thus reducing their morbidity and mortality rates. Imaging plays a significant role not only in detection but also, owing to the new functional techniques including perfusion MRI, in staging and directing treatment planes. In this article we review the different perfusion techniques used in endometrial, cervical and ovarian malignancies and the importance and potential benefits for their use. The importance of early and proper diagnosis of gynecologic malignancies lies in the fact that they contribute to a large number of female mortality and morbidity in the United States. Abbreviations: MRI: Magnetic Resonance Imaging; DCE-MRI: Dynamic Contrast Enhanced MRI; MVD: Microvessel Density; VEGF: Vascular Endothelial Growth Factor; IAUGC: Initial Area Under the Gadolinium Concen...