Juniper Publishers-Cancer Therapy Oncology International Journal

Extramedullary Myeloma   Authored by Nahla A M Hamed xtramedullary myeloma (EMM) is the presence of clonal plasma cells (PCs) outside the bone marrow in a patient with multiple myeloma (MM). EMM can be present at the time of initial diagnosis (primary EMM) or at the time of relapse (secondary EMM) [1]. EMM has an incidence of 7% to 20% at presentation and 6% to 20% during disease progression [2]. Using sensitive imaging techniques including MRI and PET/CT, EMM may be found in up to 30% of MM patients across the overall disease course [3]. Blade et al.  [4] proposed two distinct mechanisms of EMM: direct extension of bone plasmacytomas with cortical destruction and hematogeneous dissemination of myeloma cells to an anatomical site distant from the bone marrow. Extramedullary spread can be triggered by an invasive procedure (surgery or catheter insertion) or by a bone fracture [3]. To Read More Full Text .. click on https://juniperpublishers.com/ctoij/CTOIJ.MS....

Thigh Muscle Bundle Volume by Magnetic Resonance Muscle Quantification (MRMQ) in Skeletal Muscle Wasting and Relevance of Supine Rest Authored by Somya Aggarwal MRI is beginning to be extensively used in clinical trials in the quantitative analysis of muscle volume in muscle wasting pathologies with the help of magnetic resonance muscle quantification (MRMQ). Muscle wasting occurs in various kinds of diseases, such as, muscular dystrophies, cachexia, sports injuries or ageing. This can results in progressive disability and eventually a possible deformity. Clinical trials are increasingly done to target an increase in the muscle volume by new drugs. The variability in measurement of the change in muscle volume needs standardization with accurately delineated measurement methods such as mid -thigh muscle bundle volume changes. To Read More.. Full Text  in Cancer Therapy & Oncology International Journal  in Juniper Publishers