Juniper Publishers-Cancer Therapy Oncology International Journal

  Cancer Therapy & Oncology International Journal Abstract Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that may affect any portion of the gastrointestinal tract. Surgical resection was previously considered the only treatment modality available, thus prognosis in patients with advanced disease was poor. The emergence of novel therapeutic agents such as imatinib mesylate has altered how physicians now approach and manage these unique malignancies. The addition of these targeted agents has resulted in a significant benefit in median overall survival. Imatinib treatment is generally well tolerated. Side effects such as oedema, rash and gastrointestinal upset may be observed. However respiratory complaints are exceedingly rare. We report a case of imatinib-induced interstitial pneumonitis after five months of treatment in a patient with intermediate risk gastrointestinal stromal tumor of the stomach. Keywords: Imatinib Mesylate; Glivec; Inter...

  Cancer Therapy & Oncology International Journal Abstract The purpose of the work was to study the effect of different single radiation doses of X-rays on the pediatrics Rhabdomyosarcoma (RMS) cells in vitro . In addition, to construct the survival curve for the RMS cells and determine some crucial radiobiological parameters used for calculations of tumor cell kill in radiotherapy treatment of pediatrics RMS tumors. An established in vitro cell culture model employing the RMS tumor cell lines was used for this study. Cells were exposed to single doses of 0, 4, 8, 12, 16, and 20 Gy from a 6 MV X-rays photon beam energy. The clonogenic cell survival assay method was used to quantify the RMS cell survival. The survival curve was fitted by the single-hit multi-target and linear-quadratic models. The mean lethal dose (D 0 =3.2 Gy), the extrapolated number (n=11) represents a measure of the width of the survival curve shoulder and corresponds to th...

  Chimeric Antigen Receptor Engineered T (CAR-T) Cells and Cancer Therapy Editorial Gene therapy has demonstrated significant potential as a cancer therapy in the last few years. The greatest successes have been reached by genetic modification of autologous patient T cells with chimeric antigen receptors (CARs), which are novel and synthetic receptors composed of the antigen-binding domain from a B cell receptor fused to the signaling elements associated with a T cell receptor [1]. CAR-T cells are targeted towards malignant cells expressed defined associated antigens. CAR-T cells can overcome the major challenges of immunotherapy such as tolerance to self-antigens and cancer immune system evasion mechanism [2]. Structure of CAR CAR is composed of an extracellular antigen-bindingdomain derived from an antibody (mostly a single-chain fragment of vari...

  Cancer Therapy & Oncology International Journal Abstract Aim: To determine the utility of routine distal loopogram before stoma reversal and its impact on the management of patients with a low rectal anastomosis. Methods: This is a retrospective review of a prospectively maintained database of the patients underwent stoma reversal between June 1, 2011, and July 31, 2015. Primary variable assessed was accuracy of findings on preoperative distal loopogram in predicting postoperative complications after stoma reversal. Secondary variable was accuracy of findings on colonoscopy in predicting postoperative complications after stoma reversal. Results: One hundred fifty-seven patients who underwent stoma reversal were included in the study. Distal loopogram was found to be abnormal in 23 patients (15%). Overall, 17 patients developed postoperative complication in the form of anastomotic leakage or subacute intestinal obstruction. Colo...

  Cancer Therapy & Oncology International Journal Abstract The place of quackery is important in the history of medicine. In this context, cancer quackery is in the forefront of it. Therefore, English literature and foreign translations are searched from 1635 to1886 in order to obtain some memorable perspectives of the psychological aspects of cancer quackery. Keywords: Quackery; Cancer; Treatment; Psychology; History Historical Perspectives Sir Macfarlane Burnet [1], who is far famed for his pioneer work on cancer surveillance, recommended clearly in his Brailsford Robertson Memorial Lecture that scientists should acquaint themselves with historical antecedents. Therefore, this paper documents such antecedents in respect of the drug treatment modalities used by cancer quacks. Quacks were presented in the 1725 History of Physic by Friend [2] concerning “how much ...

  Cancer Therapy & Oncology International Journal Abstract Tumor heterogeneity, especially intra-tumor heterogeneity, is a crucial factor underlying difficulties in cancer treatment and failure of a number of current therapeutic modalities, even of molecularly targeted therapies. The conventional follow-up care is based on regular observation of protein markers in combination with computed tomography (CT)/positron emission tomography (PET) imaging to monitor stable disease or tumor progression. More recently, the implementation of a noninvasive “liquid biopsy” has been destined to capture tumor-specific genetic clonal evolution throughout the course of cancer therapy. This case report focuses on circulating cell-free tumor DNA (ctDNA) in the bloodstream as a versatile biomarker, enabling accurate monitoring of tumor burden and treatment response. Our observations showed that [1] mutation load measured by blood-drop ctDNA sequencing correlated well with PE...