Juniper Publishers-Cancer Therapy Oncology International Journal

  Cancer Therapy & Oncology - Juniper Publishers Abstract Protocol FOLFOX4 is a promising treatment option in advanced hepatocellular cancer patients as shown by Asian phase III trial - the EACH study. Given that most of the targeted therapies have not proven to be clinically significant or clinically relevant in the treatment advanced hepatocellular cancer, only sorafenib is at present an approved option the world over. Since sorafenib is not an affordable option, especially in developing countries where the burden is highest or for those who cannot be qualified for sorafenib in the western world, what are other options. After a thorough literature review it seems that if not Sorafenib, then probably we can treat patients with advanced hepatocellular cancer with chemotherapy protocol FOLFOX4. FOLFOX4 protocol has proved its safety and efficacy among advanced hepatocellular cancer patients in a phase III randomized trial - the EACH trial. EACH trial showe...

 Cancer Therapy & Oncology - Juniper Publishers Editorial Cancer is a group of disease characterized by the uncontrolled growth and spread of abnormal cells which may lead to death. According to a report by GLOBOCAN the number of new cancer cases would increase to 19.3 million by 2025 worldwide. Thus globally cancer has become a big threat to human beings, among various diseases. Carcinogen induced deregulation in cellular signaling pathway, may leads to the cancer development. Chemotherapy is an important mode of cancer treatment that used to cure and improve the patient’s quality of life [1]. At the same time chemotherapy is known to induce drug resistance and toxicity that hurdles the improvement of overall response and survival of cancer patients. Many cancers contain a sub-population of self-renewing and expanding stem cells known as cancer stem cells (CSCs). These are associated with chemotherapeutic resistant leading to tumor recurrence and poor pa...

Cancer Therapy & Oncology - Juniper Publishers Abstract This article aims to standardize terms used in Surgical Oncology that are the basis for the treatment of cancer patients. Terms like: Patient out of cancer treatment, Patient in stage IV, In block tumor resection, Ganglionic relay, Local and regional control, Systemic Control, Unknown Primary Origin, Unresectability, Inoperability, Multiple Organ Resection, Preoperative Nutritional Status, Minimum Oncologic Procedure, Resection margins, Prognostic Factors, Peritoneal Washing Cytology, Adjuvant, Neoadjuvant and Peri-adjuvant Therapy. Keywords: Basic terms in Surgical Oncology; Cancer Surgery Abbreviations: OCT: Patient Out of Cancer Treatment; UPO: Unknown Primary Origin; BMI: Body Mass Index. Introduction There are basic oncological principles universally accepted and those principles were born from the experience accumulated in Cancer Treatment Centers after years of observing the results ...

Pharmacology & Clinical Research-Juniper Publishers Abstract Dilated Cardiomyopathy is a rare condition that can be caused by a variety of common morbidities. It is an immune mediated disease, characterized by chronic stimulation of inflammatory responses. The so far available treatment consists of agents that ameliorate only the functional burden off the circulatory system. Biological therapies have been successfully applied in several diseases derived from hyper activation of the immune system. In this mini review we investigate whether abatacept, a biological agent targeting co-stimulation, could be beneficial in inhibiting pathophysiological progression of DCM. Dilated Cardiomyopathy–Introduction Dilated cardiomyopathy is the most common cardiomyopathy. It reflects a functional state where the anatomic structures of the heart cannot support a proper blood circulation. Dilated cardiomyopathy is not ...

Cancer Therapy and Oncology — Juniper Publishers Abstract Poorly differentiated neuroendocrine tumors are uncommon neoplasms of the lung and the gastrointestinal tract. However, 3–5% of these tumors are diagnosed as metastatic disease with unknown primary. Here, we describe a case of neuroendocrine small cell carcinoma of unknown primary diagnosed by inguinal node biopsy. A 53-year-old male patient with a history of heavy smoking presented with cough, back pain and altered mental status. Whole body imaging studies (CT — MRI — FDG PET) favored a diagnosis of hematological disease (lymphoma) or diffuse metastatic melanoma. However, inguinal node biopsy revealed morphological and immunohistochemical features of a neuroendocrine carcinoma, probably originating from the lung. The patient received palliative whole brain irradiation and etoposide/platinum-based chemotherapy. Abbreviations:  CUP: Cancer of Unknown Primary; IHC: Immunohistochemistry; CT: Computed Tomo...

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